BIOKMOD 5.0, a Mathematica tool for biokinetic modeling, fitting and
- To: mathgroup at smc.vnet.net
- Subject: [mg109163] BIOKMOD 5.0, a Mathematica tool for biokinetic modeling, fitting and
- From: Guillermo Sanchez <guillermo.sanchez at hotmail.com>
- Date: Wed, 14 Apr 2010 23:12:41 -0400 (EDT)
New version 5.0 of BIOKMOD is available at http://web.usal.es/guillermo/biokmod.htm This version expanded considerably version 4, including practically all ICRP current isotopes. Mathematica 7 is required. The program help has been enhanced. It is included some notebooks where they are described details (computations) of papers published by the author. I think it can be very useful for education purpose. To run BIOKMOD with all capability it is necessary Mathematica however BIOKMODWEB, a webMathematica application, has some of the most usual features of BIOKMOD. BIOKMODWEB can be run directly at: http://www3.enusa.es/webMathematica/Public/biokmod.html. The version includes (i) a package to solve system of ordinary linear differential equations (SOLDE) with special application to compartmental and physiological models; (ii) A package for fitting data, it can be applied to fit the transfer rates using experimental data; iii) A specific package for optimal design; iv) Some packages for solving the currents ICRP Models, they have special applications to calculate internal dose and bioassay data evaluations. Some tutorials are included about: i) Compartmental and physiological modeling (linear and non linear), ii) Random intakes in occupational exposures and their implication in the bioassays, iii) Analyticalmethods to evaluate the uncertainties associated with the biokinetic model parameters, iv) Non linear regression techniques to the bioassay data fitting, v) Optimal design applied to perform bioassay programs BIOKMOD has the following features to our knowledge are not included in any other. a) The user himself can build compartmental models in a very easy way generating automatically the system of differential equations and their solutions b) It gives analytical and numerical solutions (other codes only give the numerical). Even the solutions can be given as function of some parameters. The accumulated disintegrations in a compartment or region can be computed exactly by analytical integration, what is more precise than the method of the mean resident time often applied for other codes. c) Apart from acute, chronic and multi-inputs, it can practically be used for any kind of continuous inputs (exponentials, periodic, etc.), even for random inputs. d) The intakes can be estimated fitting bioassay data where not only the intake quantities but also other parameters (AMAD, f1, etc.) can be also assumed unknown. For non linear fitting are applied the optimization algorithm included in Mathematica and specific method as the maximum likelihood. e) Analytical expressions instead of simulation can be used for sensitivity and uncertainty analysis. f) Optimal design tools. g) The full version included practically all Currents ICRP Models. The help includes many examples. There are some publications where BIOKMOD has been used (some available at the author website Comments are welcome Guillermo Sanchez http://web.usal.es/guillermo