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Another simplification question

• To: mathgroup at smc.vnet.net
• Subject: [mg95068] Another simplification question
• From: TL <latev at shaw.ca>
• Date: Mon, 5 Jan 2009 03:27:59 -0500 (EST)

Is there a way to do this in Mathematica:

expr=(a very long and complex expression involving a b c d ...z as well 
as many x1 x2 y1 y2...)

I'd like to simplify it, by setting dist=Sqrt[(x2-x1)^2+(y2-y1)^2]
in order to do that I have to rearrange expr, so I can substitute as 
many (x2-x1)^2+(y2-y1)^2 instances as possible.
How do I tell Mathematica to rearrange expr the way I need it, or better 
yet - to do the substitution automatically for me

Thanks in advance!