Using Mathematica for Electrophysiology Data Analysis

• To: mathgroup at smc.vnet.net
• Subject: [mg110386] Using Mathematica for Electrophysiology Data Analysis
• From: François Blumenfeld <hypotyposis at me.com>
• Date: Wed, 16 Jun 2010 05:38:25 -0400 (EDT)

```Hi,

I'm playing around with Mathematica to analyze some electrophysiology
data; this is on my recreation time, so apologies if the following
questions are very basic.

I've imported data (pairs of time points and amplitudes) from pClamp
into Mathematica as lists. The lists are pretty huge (around 150,000
elements per list-I've separated times and amplitudes in two lists).
I've created a histogram of the amplitudes list, letting Mathematica
decide which binning method to use and the width of the bin. Without
user input, it actually did a great job at picking bin width and
binning method; but I don't know how to retrieve that information:
i.e. what bin width was picked and what binning method used for a
particular histogram?

My second question is about fitting a multivariate Gaussian
distribution to a multimodal (usually bimodal) histogram. I've payed
around with NonLinearModelFit, but for some reason I don't think I'm
doing it correctly. My third question is related to this: how do I
retrieve the processed data from the histogram to construct a
frequency table? I'm guessing that this might in fact be the
intermediate step I need to complete before being able to fit a curve
to the histogram data.

Any suggestions welcome!

Francois Blumenfeld-Kouchner

```

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